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Abstract

COMPARATIVE STUDY OF SUSTAINED RELEASE TABLET OF DICLOFENAC SODIUM PREPARED BY THREE TECHNIQUES (MATRIX, RESERVOIR AND OSMOTIC PUMP TYPE)

Sunil Kumar Shah*, Pradeep Sharma, Hemant Sharma, Harish Pandey, C. K. Tyagi, Neelesh Chaubey

ABSTRACT

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), taken to reduce inflammation and as an analgesic reducing pain in certain conditions. The aim of this investigation was preparation and comparative evaluation of fabricated Matrix (M), Reservoir (R) and Osmotic Pump (OP) tablets for sustained delivery of Diclofenac Sodium (DS). All formulations were evaluated for various physical parameters and in vitro studies were performed on USP dissolution apparatus II in pH 6.8 buffer and the results of tablet prepared by three techniques, were compared. Osmotic pump type tablets showed more prolonged and sustained DS release compared with Matrix tablet and Reservoir type tablets studied. The rate and extent of drug release from OP was significantly different from that of MT & RT. Type of porosigenic agents and osmogens also influenced the drug release. Analysis of in vitro data by regression coefficient analysis revealed zero-order release kinetics for OP tablets, while MT tablets exhibited Higuchi kinetics. It was concluded that the osmotic pump tablets could provide more prolonged, sustained and gastrointestinal environmental-independent DS release that may result in an improved therapeutic efficacy and patient compliance.

Keywords: Matrix tablet, Osmotic Pump (OP) tablets, Reservoir type tablets.


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