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Priya G. Shete*, Neha G. Shete*, Rupali H. Tiple, Prajakta N. Dongare and Vaishali P. Wasnik


Regulated drug release in zero-order manner attained in the current study indicates that the optimized Sustained Release tablet of Voriconazole, prepared using HPMC K100M as a polymer, ethyl cellulose, Sodium CMC and lactose used as a diluents. Magnesium stearate was used as a lubricant and Talc was used as a glident. These sustained release tablets can release the drug up to 12 hours in predetermined rate. The formulated powder blend was evaluated for bulk density, tapped density, compressibility index and angle of repose. The formulated tablets were evaluated for physical characteristics of sustained release tablets such as thickness, hardness, friability, weight variation and drug content. The results of the formulations found to be within the limits specified in official books. The tablets were evaluated for In-vitro drug release studies by using USP type I dissolution test apparatus. The dissolution test was performed in 0.1 N HCL for 2 hr and phosphate buffer pH 6.8 for 10hrs. The in-vitro cumulative drug release profile of all formula-tions F1-F10 at 12 hours showed 97.35% to 99.56% drug release, respectively. From the data it was clear that by increasing the amount of polymer in the formulation the amount of drug release was decreased. Hence, Formulation F7 was the most promising formulation as it gives satisfactory release (99.56%) for 12 hours and F7 found to be the best formulation.

Keywords: Voriconazole, HPMC K100M, Sodium CMC, Ethyl cellulose, Release kinetics.

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