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  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

FORMULATION AND EVALUATION OF BUCCOADHESIVE PATCH CONTAINING ANTIHYPERTENSIVE DRUG

Vaishali P. Wasnik*, Rupali Tiple, Prjakta Dongare and Priya Shete

ABSTRACT

In this investigation, buccal patch of valsartan was prepared using different concentration of Poylethylene glycol 6000 by solvent evaporation method and were evaluated for thickness, drug content uniformity, bio-adhesion strength, % swelling index, folding endurance and in vitro drug release. A combination of Carbopol 934P and Eudragit NE 30 D controlled the drug release for 8 hrs also gives better muco-adhesion strength and time. In vitro drug release studies reveal that all patches exhibited sustained release in the range of 58.45 to 95.67 % for a period of 8hours.

Keywords: Valsartan; Eudragit NE 30 D; Carbopol 934P; Poylethylene glycol 6000; Muco-adhesive buccal patches.


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