Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

FORMULATION AND CHARACTERISATION OF TRIAMCINOLONE ACETONIDE EMULGEL

Reha Chodankar* and Asish Dev

ABSTRACT

The objective of the study was to increase the solubility and permeability of Triamcinolone acetonide by formulating an oil-in-water emulgel using HLB system for preparation of emulsions. The active moiety was solublised using oil (Liquid paraffin) and N- Methyl Pyrolidone which acts as a solubliser and also helps in effective permeation. The emulsion was prepared by using HLB system that calculated the optimum quantity of emulsion blend i.e. 30% Span 80 and 70% Tween 80. Further the emulsion ratio was varied (2%, 4%, 6 %) and it was found that 6% was stable amongst the three. The prepared emulsion was then incorporated in carbopol 934 as it was low viscous then carbopol 940 that would facilitate effective release of the gel. The oil and gel concentration were varied from 5, 8, 10% and 1, 1.4, 1.8% respectively. The above formulated emulgel was then subjected to evaluation parameters of emulgel like physical properties, spreadability, extrudability, rheological properties, bioadhesive strength measurement, drug content determination, In-vitro release study, drug release kinetics. From In-vitro release study it was concluded that the optimised batch LP-F (Oil-10%, Emulsifiers- 6% and Gel- 1.4%) showed a sustained release of 96.50% in 7hrs.The Ex vivo studies carried out for the optimised batch showed a maximum release of 108.47 in 6 hrs. Thus, it can be concluded that Triamcinolone acetonide was proven to be a suitable candidate for formulating emulgel for topical delivery to achieve better patient compliance.

Keywords: Emulgel, hydrophobic drug, topical preparation, HLB system.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More