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Abstract

FORMULATION AND EVALUATION OF OLANZAPINE NIOSOMAL SUSPENSIONS FOR BRAIN TARGETING

Tejaswi lella*, M.Kishore babu

ABSTRACT

The aim of this research activity is to formulate Olanzapine Niosomal suspensions with a view to targeting the drug to the brain and produce a sustained release to increase the retention time of the drug in the brain. Olanzapine Niosomal suspensions were formulated by Thin film hydration technique. Relationship between type and molar concentration of surfactants, cholesterol and characterization parameters of niosomes was established. Influence of Span 20, Span 60 and Span 80 surfactants with different molar concentrations of cholesterol were studied. Particle size and scanning electron micrographic analysis reveal the presence of well identified and nearly perfect spheres within nanosomal size range. The higher values of entrapment efficiency (50.83-61.42%) were observed for the niosomes made with span 60 surfactant. Span 20 niosomal formulations showed better entrapment efficiency than span 80 formulations. Drug entrapment efficiency was found to be increased with the increase in molar concentration of cholesterol. The highest percentages of drug released (72.57% and 75.30%) were obtained with F5 and F4 formulations which were prepared with Span 60. The drug release from Span 20 and 80 formulated niosomes seems slower than Span 60 formulations. In-vitro diffusion studies of the formulations followed first order kinetics and ascertained peppa's mechanism, governed by non-Fickian diffusion. Zeta potential value of the formulation F5 was found to be -78.8mV indicating high negative surface charge on niosomes indicating high stability. From the results it can be concluded that the niosomal formulation F5 could be a better choice in the view of entrapment efficiency and drug release rate for the effective management of psychotic disorders.

Keywords: Niosomes, Olanzapine, Thin film hydration technique, In-vitro diffusion studies.


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