FORMULATION AND EVALUATION OF OLANZAPINE NIOSOMAL SUSPENSIONS FOR BRAIN TARGETING
Tejaswi lella*, M.Kishore babu
ABSTRACT
The aim of this research activity is to formulate Olanzapine Niosomal
suspensions with a view to targeting the drug to the brain and produce
a sustained release to increase the retention time of the drug in the
brain. Olanzapine Niosomal suspensions were formulated by Thin film
hydration technique. Relationship between type and molar
concentration of surfactants, cholesterol and characterization
parameters of niosomes was established. Influence of Span 20, Span 60
and Span 80 surfactants with different molar concentrations of
cholesterol were studied. Particle size and scanning electron
micrographic analysis reveal the presence of well identified and nearly
perfect spheres within nanosomal size range. The higher values of
entrapment efficiency (50.83-61.42%) were observed for the niosomes made with span 60
surfactant. Span 20 niosomal formulations showed better entrapment efficiency than span 80
formulations. Drug entrapment efficiency was found to be increased with the increase in
molar concentration of cholesterol. The highest percentages of drug released (72.57% and
75.30%) were obtained with F5 and F4 formulations which were prepared with Span 60. The
drug release from Span 20 and 80 formulated niosomes seems slower than Span 60
formulations. In-vitro diffusion studies of the formulations followed first order kinetics and
ascertained peppa's mechanism, governed by non-Fickian diffusion. Zeta potential value of
the formulation F5 was found to be -78.8mV indicating high negative surface charge on
niosomes indicating high stability. From the results it can be concluded that the niosomal
formulation F5 could be a better choice in the view of entrapment efficiency and drug release
rate for the effective management of psychotic disorders.
Keywords: Niosomes, Olanzapine, Thin film hydration technique, In-vitro diffusion studies.
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