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T. Manasa*, Y. Vishnuvandana and M. Pavani


The purpose of present investigation was to develop and evaluate Gastroretentive drug delivery system of fluoroquinolone antibiotics (Ofloxacin). Floating matrix tablets of Ofloxacin were developed to prolong gastric residence time leading to an increase in drug bioavailability. Tablets are prepared by direct compression technique using polymers HPMC K4M, CARBOPOL and KARAYA GUM. Tablets were evaluated for their physical characteristics viz., hardness, thickness, friability and weight variation, drug content and floating properties. Gas generating agent plays an important role in floating lag time and drug release. The floating lag time were found to be significantly increased with the increasing concentration of the polymers. After the dissolution study of prepared Ofloxacin floating tablet it was concluded that the formulation F7 with HPMC K4M, CARBOPOL and KARAYA GUM shows better controlled release effect (98.07%). The best formulation subjected for kinetic treatment. i.e., zero order, first order, Higuchi & peppas, and The R[2] Values are 0.963, 0.801, 0.983 & 0.601 respectively. The release kinetic data implies that the release mechanism of all the formulations was Zero order kinetics and super case II transport mechanism. The developed floating tablets of Ofloxacin may be used to prolong drug release for at least 10hours, thereby improving the bioavaibility and patient compliance.

Keywords: Ofloxacin, floating tablets, gastric residence time, Gastroretentive drug delivery system.

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