Abstract

ADAPTOGENIC ACTIVITY OF MYXOPYRUM SMILACIFOLIUM BLUME

E.N. Siju and Jolly Samu*

ABSTRACT

Ethanol and aqueous extracts of Myxopyrum smilacifolium leaves were screened for adaptogenic activity using anoxia stress tolerance model and swimming endurance model. The effect was assessed by swimming survival time and anoxia tolerance time, estimation of various biochemical parameters in swimming endurance like glucose, cholesterol, triglycerides and blood urea nitrogen and morphological parameters like weight of organ such as liver, spleen, adrenal gland, at dose of 200mg/kg, 400mg/kg body weight per oral. Blood cell count and the differential count also determined. The extracts showed significantly increases the swimming endurance time and anoxia tolerance time. The extracts showed significant decrease in biochemical parameters, organ weights and increases the weight of spleen. Thus the obtained results revealed that the Myxopyrum smilacifolium may have a significant adaptogenic activity.

Keywords: LD50; Adaptogen; Anoxia stress tolerance; Swimming endurance; Myxopyrum smilacifolium.