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  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

A VALIDATED STABILITY INDICATING REVERSE PHASE LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF VALACYCLOVIR.

S. Sreenivasulu*, M. Rameswara Rao and K. B. Chandra Sekhar

ABSTRACT

A simple reverse phase liquid chromatographic method with ultraviolet detector was developed for the accurate determination of Valacyclovir using GracesmartRP18, C18 Column (250 mm × 4.6 mm, 5 μm particle size). The mobile phase used for the determination was Methanol: Citric Acid buffer in a ratio of 60: 40 v/v at a flow rate of 1.0 mL per min. Valacyclovir was eluted at 2.2 ± 0.1 min and detected at 254 nm. The method is linear over the concentration range of 10-50 μg/mL with correlation co-efficient r2 = 0.999. The plate count and tailing factor was found 3847 and 1.24 respectively. The developed method was proved to be robust after extensively validated with different parameters such as Linearity, Precision, Accuracy, Robustness, Ruggedness, Limit of Detection (LOD), Limit of Quantification (LOQ) and specificity. The validated method is definite, meticulous and reproducible and can be used for routine analysis of Valacyclovir in bulk form.

Keywords: Valacyclovir, C18 Column, Methanol: Citric Acid buffer (60:40), UV detector 254 nm.


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