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Abstract

FORMULATION AND EVALUATION OF OSMOTICALLY CONTROLLED RELEASE TABLETS OF TRAMADOL HYDROCHLORIDE

Sudhamani Kotturu*, Mamidi Anand Kumar and Gudipally Priyanka

ABSTRACT

In the present study elementary osmotic pumps (EOP) of tramadol hydrochloride were formulated and evaluated. The control release profile was selected and different variables were optimized to achieve the same. Formulation variables like type of osmogen, concentration of osmogen and aperture diameter and were found to affect the drug release from the developed formulations. The tablets prepared with potassium chloride as osmogen has shown good release andt the release rate was more with an increase in orifice size. The correlation coefficient R2 value obtained for zero order was found to be superior on comparision with first order kinetics. R2 value for higuchi plot was 0.928, it indicates diffusion controlled release.

Keywords: Elementary osmotic pumps, tramadol hydrochloride, osmogen.


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