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*Sefeera A.A., Prof. Junise V., Prof. Dr. T.N.K. Suriya Prakash, Hafsa P. V. and Ajith Chandran


The present study deals with the formulation of Chitosan Microsphere loaded with Rifampicin with a view to developing an extended release formulation. In this preparation, polymers (chitosan and sodium alginates) were used with a fixed concentrations of Rifampicin [(1:1:1), (1:1:2), (1:1:3), (1:1:4), (1:2:1), (1:3:1), (1:4:1) and (1:2:2)] by ionotropic gelation/ external gelation technique. All formulations show good flow properties and compatibility studies show that there was no interaction between drug and carrier used. The principle involved was the cation-induced gelation of alginate, for the simultaneous encapsulation of rifampicin. Ionotropic gelation was applied to prepare microspheres using combinations of chitosan and Ca2+ as cationic components and alginate as the anion. The prepared Rifampicin microspheres are shown red color with elegant appearance, before drying and on drying, it appeared as reddish brown color. SEM and particle size analysis reported that the size of the particles was in micrometer range and all formulation showed average particle size below 10μm and with good % yield, good %drug content and %encapsulation efficiency. Results of dissolution studies show that formulation 3 (RM-3) gives good release profile compared to other formulations. A n d pharmacokinetic evaluation shows all the formulation shows zero-order kinetics with the Non- fickian mechanism of release.

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