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Abstract

“FORMULATION AND EVALUATION OF ATENOLOL TRANSDERMAL DRUG DELIVERY SYSTEM”

*Ramachandra M. Koli and Ritesh S. Bathe

ABSTRACT

The present study was carried out to develop the transdermal patches Containing Atenolol with different polymers of HPMC, PVPK30 and EC was added in the formulation Propylene glycol used as a plasticizer, DMSO, ethanol and eugenol is used as penetration enhancers. Solvent Casting method was used for the formulation of patches. The patches showed satisfactory folding endurance and tensile strength. And it indicated good physical stability. The drug-excipients compatibility studies were performed by Fourier Transform Infrared spectrophotometer (FTIR). The diffusion studies were performed by using modified Franz diffusion cell. In -vitro drug permeation test was carried for 24 hrs. F6 contain Eugenol is used as natural penetration enhancer it shows maximum drug permeation 96.45% of at the end of 24 hrs. Due to which reported that penetration enhancers had functional groups with hydrogen- bonding ability effectively improving the drug transport through skin and also improvement in the partitioning of the drug to stratum corneum. The mechanism of drug permeation was followed diffusion controlled by zero order and Higuchi matrix kinetics respectively.

Keywords: Atenolol, Matrix type transdermal patch, HPMC, PVPK30 and EC, Solvent Casting method.


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