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Tatapudi Naga Aparna* and Dr. Ambati Sambasiva Rao


Development of liquisolid compacts is one of the new pharmaceutical formulation technologies to improve the dissolution rate of poorly soluble drugs. The intent of present investigation was to enhance the dissolution rate of poorly soluble drug Domperidone by delivering the drug as a liquisolid compact. Liquisolid powder systems were developed using Tween 80 as solvent, Neusilin, Fujicalin and Avicel PH 102 as the carrier powders and Cab – o – sil M5 as the coating material. Liquisolid systems with Neusilin as carrier material displayed good flow properties. The physico–chemical properties of liquisolid systems were evaluated by Infrared spectra analysis (IR), Differential scanning calorimetry (DSC) and X- ray diffraction (XRD). DSC and FTIR studies revealed that there was no interaction between the drug and carrier. XRD studies demonstrated that there was a significant decrease in crystallinity of pure drug present in liquisolid system. The dissolution studies, for the liquisolid powder systems and pure drug were carried out to determine the improvement in dissolution rate and finally the best formulation was formulated into sublingual tablets and was subjected to stability studies to assess the drug stability in the formulation. These tablets, apart from fulfilling the official and other specifications, exhibited higher rates of dissolution and dissolution efficiency values compared to their commercial counter parts. Mathematical modeling of dissolution data shows fitting into first order kinetics. From the stability studies, the similarity index was found as 88.01 indicating the stability of drug in the formulation.

Keywords: Domperidone, Tween 80, Neusilin, Similarity factor.

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