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  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

PREPARATION AND EVALUATION OF GLIPIZIDE ORAL CONTROLLED RELEASE MATRIX TABLETS USING AVENA SATIVA GUM

P. N. Mallikarjun*, K. E. V. Nagoji and Y. Srinivasa Rao

ABSTRACT

The main purpose of the present work is to study Avena Sativa gum (ASG) functionality as a release retardant agent in the development of oral controlled release matrix tablets of Glipizide. ASG extracted from oats (Avena Sativa) by an established method. Fourier transform infrared spectroscopy studies were performed to find out the interactions between gum and drug. Here matrix tablets of Glipizide were prepared with ASG alone and in combination with PVP by wet granulation technique. The granules were evaluated for angle of repose, bulk density and compressibility index. The granules showed satisfactory flow properties. Tablets thus formulated were evaluated for various quality control tests like weight variation, hardness, friability etc. All Glipizide matrix tablets were found to have better uniformity of weight and drug content with low SD values. The dissolution study proved that the ASG can be used as a matrix forming material for making controlled release tablets. The kinetic release data fitted into different mathematical models (Zero order, First order, Higuchi, Peppa’s and Hixson-Crowell). Most of the solid matrix formulations followed Higuchi or zero order kinetics.

Keywords: Glipizide, Avena Sativa gum (ASG), matrix tablets.


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