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Abstract

ANTI-FILARIAL EFFECT OF ANTIBIOTICS AGAINST PARASITE SETARIA CERVI: ROLE OF OXIDATIVE STRESS

D. Madkoriya, KN Sahare*, RK Patidar, M. Khare, and V. Singh

ABSTRACT

World health organization highlighted the requirement for development of new drugs for filariasis. In the present study antifilarial screening was carried out against Setaria cervi adult filarial with varying concentrations of Tetracycline, Rifampicin and Doxycycline (2 - 20 mg/ml) individually to find out any involvement of oxidative mechanism in the anti-filarial effect of these antibiotics in vitro. Reduction in motility of the adult was measured after 24h in terms of MTT reduction assay and correlated with the levels of MDA and nitric oxide. Significant reduction in motility was recorded with increasing concentration of Tetracycline and Rifampicin but with Doxycycline the effect was not marked. Antibiotics with high antifilarial activity revealed significant association with oxidative stress parameters in a dose dependent manner. The results suggest that oxidative stress might be exploited to design and development of novel antifilarial drug candidate.

Keywords: Antibiotics, Anti-filarial, Oxidative stress, Drug designing.


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