Abstract

REGULATION OF ANTIOXIDANT ENZYMES LEVELS IN RAT BRAIN – A SIGNIFICANT ROLE OF NASTURTIUM MICROPHYLLUM EXTRACT

Sandhyarani Guggilla* and Manda Sarangapani

ABSTRACT

Objective: The whole plant of Nasturtium microphyllum. is used traditional Indian medicine to treat epilepsy. Previous studies have demonstrated that extracts of these plants was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. Method: The purpose of the present study is to investigate the effect of ethanolic (95%) extract of Nasturtium microphyllum. (EENM) on antioxidant enzymes in rat brain after induction of seizures by MES and PTZ. Results and Discussion: Our aim of study was relationship between seizure activities and altered the levels of antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GP), glutathione reductase (GR), catalase and lipid peroxidation on rat brain. Superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase was decreased in rat brain due to seizure and it was restored significantly by administration of ethanol extract of Nasturtium microphyllum. treated rats. Similar dose dependent results were obtained in PTZ model also. Whereas EERS significantly decreased lipid peroxidation in both models. Conclusion: The anticonvulsant activity of EERS might be presents of antioxidant properties and it delays the generation of free radical in MES and PTZ induced epilepsy.

Keywords: Antioxidant Enzymes, Nasturtium microphyllum, Superoxide Dismutase (SOD), Glutathione Peroxidase (GP), Glutathione Reductase (GR), Catalase and Lipid Peroxidation.