Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2021 Issue has been successfully launched on 1 March 2021.

Abstract

DEVELOPMENT AND OPTIMIZATION OF SUSTAINED RELEASE IN SITU GEL FOR THE TREATMENT OF ULCERATIVE COLITI

Gajendra Chaudhary*, Dr. Beny Baby, Dr. B. Prakash Rao, S. Rajarajan, Jitendra Sah, Umesh Acharya

ABSTRACT

The objective of the research work was focused on optimization and evaluation of Mesalamine rectal in-situ gel of controlled/sustained release. This is used as anti- ulcerative colitis drug, for pediatric dose. The in-situ gel formulation were prepared by simple mixing method it’s a cooling technique based on the temperature triggering system by incorporation of various polymers like Poloxamer 407 and HPMC E-50 in different proportions. The in-situ gel characteristics were evaluated for clarity, gelation time, gelation temperature, gel strength, and in-vitro drug release studies. The formulations gave an initial burst effect and followed by sustained release for 12 h. Optimized formulation showed release of drug up to 92.860% in 12 h. Optimization was done by using design expert software. The optimized formula (F3) showed no significant changes on stability studies when stored at 40ºC/75% RH for one month according to ICH guidelines.

Keywords: Rectal In-situ gel, Mesalamine, Pluronic F-127, HPMC E50, Pediatric dose.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More