Abstract

EFFECT OF RESVERATROL WITH VITAMIN C COMBINATION TREATMENT ON STREPTOZOTOCIN INDUCED DIABETIC RAT RENAL IMPAIRMENT

*Jalaiah M., Dr. Dhachinamoorthi D., Raviteja T. and Purnima Devi A.

ABSTRACT

Objective: The present study was under taken effect of resveratrol with vitamin C combination treatment on streptozotocin induced diabetic rat renal impairment and to examine the effect of this combination on tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL6). Methods: Group-I: Normal control rats, Group-II: STZ induced diabetic rats, Group-III: diabetic rats treated with Resveratrol, Group-IV: diabetic rats treated with Vitamin C, Group V: diabetic rats treated with resveratrol and Vitamin C combination. Results: The present study strongly suggest that resveratrol with vitamin C combination treatment effectively prevent the diabetes associated renal damage by restoring the altered biochemical parameters, rectifies the architectural alterations and by reducing expression of TNF-α and IL-6 in the kidney. Conclusion: Resveratrol with vitamin C combination could be used as an adjuvant therapy with a conventional hypoglycemic regimen to treat diabetic complications.

Keywords: Resveratrol, VitaminC, Streptozotocin, Diabetic nephropathy.