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Abstract

FORMULATION AND EVALUATION OF FAST MOUTH DISSOLVING FILM OF METOPRLOL SUCCINATE

Priyanka S. Patil*, Prof. S. G. Patil, Prof. Sandip A. Tadavi, Dr. N. A. Gujarati and Dr. Sunil P. Pawar

ABSTRACT

Mouth dissolving dosage forms are gaining popularity in recent time because of good patient compatibility, fast disintegration time, flexibility in transportation etc. In this research work Metroprlol Succinate is used to treat chronic hepatitis B. Metroprlol Succinate is an antiretroviral drug. Metroprlol Succinate is selected as model drug for the preparation of Mouth dissolving film (MDF). MDF was prepared by solvent casting method using HPMC E15 as film former and Glycerol & PEG-400 as plasticizers. MDF were evaluated for physical characteristics such as tensile strength, percentage elongation, drug content uniformity, surface pH, folding endurance, uniformity weight, and thickness and gave satisfactory result. The formulations were subjected to disintegration time, in vitro drug release test and stability study. The FTIR studies revealed that there was no physicochemical interaction between excipients and drug. The FTIR studies revealed that there was no physicochemical interaction between excipients and drug. A marked % drug release was exhibited by MDF of Metroprlol Succinate containing HPMC E15 as a polymer at 30 sec.

Keywords: Metroprlol Succinate, Mouth-dissolving film, HPMC E15, PEG-400, Solvent Casting Method.


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