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Abstract

DEVELOPMENT AND EVALUATION OF LYOPHILIZED PRODUCT OF ACETOZOLAMIDE SODIUM

Sandhyarani G.* and Sarangapani M.

ABSTRACT

 Lyophilization or freeze drying involves the removal of water or other solvent from a frozen product by a process called sublimation followed by desorption.  Lyophilization is a multistage operation in which, quite obviously, each step is critical. The main actors of this scenario are all well known and should be under strict to achieve a successful operation.  Freeze-dried products for parenteral use are known as Powders for injection or infusion. As the stability of Acetazolamide in aqueous solution form was unstable it was formulated as Lyophilized product.  The objective of the present study was to develop a stable lyophilized formulation of drug Acetazolamide sodium for injection (500mg/vial) which is therapeutically equivalent to the reference listed product, DIAMOX.

Keywords: .


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