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Mohd. Gayoor Khan* and Dr. H. S. Chandel


Histamine is the major cause of allergy, urticaria, common cold, Hay fever, food allergy, and rhinitis. In today’s life it is necessary to know about the factors that increases histamine level in the body such factors are histamine containing food or food that inhibit the enzyme diamine oxidase. Stress is an another important factor that influence the histamine level in the body and that drugs that increases the histamine level in the body .The first generation antihistaminic drugs have certain side effects but also have some special property for example- promethazine is used to control pregnancy vomiting, sialorrhoea, tremor, morning sickness and cyproheptidine is having appetite stimulant activity. The first generations antihistaminic drugs are also available in the market the main cause of it is the muscarinic receptors activity of the first generation activity. The second generation antihistamines overcome the side effects that were caused by the first generation antihistaminic drugs mainly sedation. The second generation antihistaminic have a disadvantage that they are less effective to common cold, rhinitis due to lack of muscarinic activity. The second generations drugs (cetirizine) have property to inhibiting leukotriene C4 and D4 that are main cause of asthma The future aspect is to control the release of histamine in the body by H3 antagonists. The H3 antagonists also have antidepressant activities that overcome the stress factor.

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