Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2021 Issue has been successfully launched on 1 March 2021.

Abstract

SMEDDS/SNEDDS: AN EMERGING TECHNIQUE TO SOLUBILITY ENHANCEMENT FOR THE PHARMACEUTICAL INDUSTRY

Mittal Tanya* and Kumar Hari S.L.

ABSTRACT

Most of the new chemical entity (NCE) used today have poor bioavailability due to numerous formulation related performance issues and to ensure the compliance of oral drugs for their long term use have become a prerequisites. Lipid based formulation is one of the growing and suitable drug delivery strategies to overcome the issue of bioavailability and dissolution rate of Poorly water soluble drugs (especially BCS Class II and IV) for better dispersion. Thus, it is stated that over 30% of the drug candidate’s entities are hydrophobic in nature or lacking required aqueous solubility. SMEDD/SNEDDS are isotropic mixture of oil, surfactant and co-surfactant molecules used in the formulations to improve the oral absorption of highly lipophilic drugs. These systems have unique property to form oil in water emulsion under gentle agitation provided by digestive motility of the stomach and intestine. The aim of the current review is to screen lipid excipients for their self- emulsification efficiency and to overcome the limitation of liquid SMEDDS/SNEDDS in handling, stability problem, precipitation of drug delivery fabrication and unsuitable for hydrophobic drugs. The review also aims to conversion of liquid SMEDDS/SNEDDS to S-SMEDDS/S-SNEDDS to enhance the oral bioavailability of poorly soluble and low absorption drugs of various solid dosage forms by using adsorption on solid carrier, spray drying, lyophilization, and melt granulation and extrusion techniques.

Keywords: Poorly water soluble drugs, Solid- self micro and nano emulsifying delivery, Lipd based formulation, Techniques, Bioavailability and absorption.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More