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*Nita Kishanrao Thamke and Sharad Sudhakar Kharat


The oral delivery of lipophilic drugs has a major challenge because of low aqueous solubility of drugs. Improving oral bioavailability of poorly water soluble drugs using self-micro emulsifying drug delivery systems (SMEDDS)it is also challenge. Nearly 40% new chemical substances exhibit poor water solubility, oral delivery of BCS class II and BCS class IV drugs presents a major challenge to developing formulations for such active pharmaceutical ingredients (API). Self-microemulsifying drug delivery systems (SMEDDS) have ability to increase solubility and bioavailability of poorly soluble drugs. Self-micro emulsifying drug delivery systems are isotropic mixtures of oil, surfactant, co-surfactant of co-solvents can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drugs. It can be converted into solid by suitable means can be orally administered in hard or soft gelatin capsule. These solid SMEDDS are considered more stable over liquid SEDDS, also solid forms improve handling, packaging and storage. The hydrophobic nature of drug which are studies with SMEDDS will continue and more drug compounds formulated as SMEDDS will reach pharmaceutical market.

Keywords: Self-Emulsifying formulation, Lipid-based drug delivery systems, poorly water soluble drug, Characterization, Bioavailability enhancement.

[Full Text Article]

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