Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2021 Issue has been successfully launched on 1 February 2021.

Abstract

COMPARATIVE BIOEQUIVALENCE STUDY OF DIFFERENT BRANDS OF VALSARTAN TABLETS MARKETED IN BANGLADESH BY DISSOLUTION MODELING AND QUALITY CONTROL TESTS

*Farzana Hasin, Sharja Noon, Hasib Al Hasan, Shamima Nasrin

ABSTRACT

Valsartan is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor. Valsartan is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. The objective of this study was to evaluate the suitable brand of Valsartan tablet having better dissolution profile, to evaluate study of physicochemical equivalence of different brands as well as to determine that which brand is economically as well as therapeutically effective for the patient of hypertension. Three brands (represents IMS-Health reported top to small scale companies) of Valsartan 80 mg were collected randomly from different pharmacies. Fore selected brands were coded as A, B & C. The different brands were evaluated for hardness, weight variation, disintegration, chemical assay and dissolution tests. Resul ts of different brands were found within in the limits. The chemical assay test of all the tablets showed that none had potency less than the required specifications of USP. The results of all the tests performed show that GMP and cGMP guidelines have been followed during manufacturing. This study proved the physicochemical equivalent of the four different brands. So if one brand is not available in the market than any of the other three brands can be taken in place of that unavailable brand according to the economic conditions of the patients.

Keywords: Valsartan, In-Vitro Dissolution, Disintegration Time, Physicochemical Equivalency.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More