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Abstract

COMPARATIVE IN-VITRO BIOAVAILABILITY STUDIES ON DIFFERENT BRANDS OF BACLOFEN TABLET AVAILABLE ON BANGLADESH MARKET

*Farzana Hasin, Md. Towhidul Islam, Md. Forhad Ahmad and Md. Mahadi Hasan Rakib

ABSTRACT

The presence of numerous generic brands of Baclofen in the local drug market makes the situation difficult for health professionals and patients to choose the appropriate product. This study was intended to evaluate the bioequivalence of three marketed brands of baclofen (10 mg) tablets from different manufacturers using in vitro dissolution study in order to minimize health risk factors. Drug releases were compared with that of a reference product. The dissolution profiles showed release of drug at 10, 20, 30 and 45 minutes time point. All the brands achieved 85% dissolution within 45 minutes. Test results were subjected to statistical analysis to compare the dissolution profile. Model independent approaches of difference factor (f1) and similarity factor (f2) were employed. Using a validated high performance liquid chromatography method, Other general quality parameters of these tablets like diameter, thickness, hardness, friability, weight variation, disintegration time were also evaluated and test results were within the limit.

Keywords: Bangladesh, baclofen tablet, disintegration, dissolution.


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