WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE PELLETS OF METOPROLOL TARTRATE

Mangesh R. Bhalekar*, Ashwini R. Madgulkar and Sumedha S. Andure

ABSTRACT

The objective of the study was to develop and evaluate sustained release Metoprolol tartrate pellets in the form capsule and compare with the marketed dosage form (METLOR-XR). The formulation was optimized using 32 factorial design by design expert software version 10.0. The concentration of Eudragit L-100 and concentration of PVP K-30 were chosen as independent variables. The formulated pellets were evaluated for flow properties, % drug content, in-vitro drug release, % coating efficiency, SEM, DSC and FTIR, etc. The optimized formulated batch was compared with the marketed formulation (METLOR-XR capsule). The % drug release of optimized batch hour was found to be 91.35%. The formulated batch (F1) has more drug release than marketed product and hence it has more bioavailability.

Keywords: Metoprolol tartrate, Eudragit L-100, Polyvinyl pyrrolidone k-30, Solution layering technique, pellets.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More