Abstract

STUDIES ON NOVEL 1, 3, 4-OXADIAZOLE MOIETIES CONTAINING THIAZOLIDINONE RING

Meeta A. Suthar* and M. K. Thakor

ABSTRACT

Fused heterocyclic compounds (3a-h) namely N-(3,5-diphenyl-3,3adihydro- 2H-pyrazolo[3,4,-d]thiazol-6(5H)-yl)-2-(5-phenyl-2-thioxo- 1,3,4-oxadiazol-3(2H)-yl)acetamide were prepared and characterized. First Oxadiazolo-thiazolidinones (1a-h) on condensation with benzaldehyde gives arylidine derivatives (2a-h). Such compounds 2a-h on reaction with hydrazine hydrate gives title compounds i.e. 3a-h. All the compounds were screened for their antimicrobial activity.

Keywords: Oxadiazolo-thiazolidinones, arylidine, hydrazine hydrate, antibacterial and antifungal activities.