Abstract

EFFECTS OF PROPHYLACTIC ONDANSETRON ON SPINAL ANAESTHESIA INDUCED HYPOTENSION AND BRADYCARDIA: A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND STUDY.

Dr. Amir Nazir and Dr. Feroz Ahmad Dar*

ABSTRACT

Background: The Bezold-Jarisch reflex is the likely cause of hypotension and bradycardia associated with spinal anaesthesia. The aim of this study was to investigate the effect of ondansetron (5-HT3 receptor antagonist) on spinal induced hypotension and bradycardia in caesarean section. Methods: Total hundred parturient patients undergoing caesarean section participated in the study with 50 patients in the group O which received intravenous ondansetron 1μg/kg diluted in 10ml NaCl Solution and 50 patients in group NS which received 10ml 0.9% NaCl solution five minutes before spinal anaesthesia. The heart rate, arterial blood pressure, shivering, nausea, vomiting and any other adverse effects were recorded after spinal anaesthesia. Results: Hypotension was seen only 7 patients (14%) in group O as compared to 23 patients (46%) in group NS (p

Keywords: Bezold Jarisch Reflex, Ondansetron, Hypotension, Bradycardia.