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Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL OXADIAZOLES

*Neha G. Solanki and M. K. Thakor

ABSTRACT

3-(4-(5-methyl-2-thioxo-1,3,4-oxadiazol-3(2H)-ylsulfonyl)phenyl)-2- phenylthiazolidin-4-one (1) on reaction with aromatic aldehydes yield 5-(substitutedmethylene)-3-(4-(5-methyl-2-thioxo-1,3,4-oxadiazol- 3(2H)-ylsulfonyl)phenyl)-2-phenylthiazolidin-4-one (2a-h). Further compounds 2a-h reacted with phenylhydrazine gives targeted compounds i.e. 3-(4-(3-substituted-5-phenyl-2-(phenylamino)-3,3adihydro- 2H-pyrazolo[3,4-d]thiazol-6(5H)-yl)phenylsulfonyl)-5- methyl-1,3,4-oxadiazole-2(3H)-thione (3a-h). The final compounds were characterized using CHN, IR and NMR analysis. The biological evaluation revealed that the all compounds shows good to moderate biological activity against employed bacterial and fungal strains.

Keywords: 1,3,4-Oxadiazole, Oxadiazolo-Sulfonyl-Thiazolidinones, Spectroscopic analysis, Antibacterial activity, Antifungal activity.


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