Abstract

ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF FICUS AURICULATA LOUR. LEAF EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC MICE

Rosalind Thingbaijam*, Biman Kumar Dutta & Satya B. Paul

ABSTRACT

Objective: Antihyperglycemic and antihyperlipidemic activity of Ficus auriculata Lour. leaf extract in streptozotocin induced diabetic mice. Materials and Methods: Diabetes was induced in swiss albino mice by administration of streptozotocin (70 mg/kg, i.p.). Normal as well as diabetic albino mice were divided into groups (n = 6) receiving different treatments: vehicle (control), methanol extract (300 and 600 mg/kg b.w), and standard antidiabetic drug glibenclamide (10 mg/kg b.w.). Blood samples were collected from tail for blood glucose analysis on (0th, 5th, 10th and 15th day) and animals were sacrificed on 15th day and blood sample were collected by cardiac puncture and analyzed for lipid profile. Histological studies were done on pancreas and liver respectively. Results: The methanol extract of Ficus auriculata Lour. produced significant reduction ( P < 0.001) in blood glucose and also had beneficial effects ( P < 0.05) on the lipid profile in streptozotocin induced diabetic mice at the end of the treatment period (15th day). The histopathological studies have shown to ameliorate the streptozotocin induced histological damage of islets of langerhands in pancreas and hepatocytes in liver. Conclusion: We concluded that methanol extract of Ficus auriculata Lour. is effective in controlling blood glucose levels and improves lipid profile in streptozotocin induced diabetic mice.

Keywords: Antihyperglycemic, antihyperlipidemic, Ficus auriculata Lour., glibenclamide, histopathological, streptozotocin.