Abstract

COMPARATIVE STUDY OF DICLOFENAC AND DICLOFENAC WITH MEFANAMIC ACID IN OSTEOARTHRITIS PATIENTS

J. Subadra Devi*, Saranya Shanmuga Priya and R. Sivasakthi

ABSTRACT

The Prospective observational study was conducted with aim of compare the effect of diclofenac and diclofenac with mefanamic acid in arthritis patient. The 6 months duration study was with 100 patients and were selected randomly as per the inclusion criteria. The reduction in pain was measured at baseline, 2, 4 and 6 months by using Visual analogue scale (VAS) method. The pain was reduced high in Diclofenac with mefanamic acid than Diclofenac alone. Epigastric pain was the major adverse drug reaction in 30% in combination therapy. The efficacy, tolerability and remarkable reduction of pain and stiffness are found with Diclofenac with mefanamic acid.

Keywords: Diclofenac, Epigastric pain, reduction, pain and stiffness.