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Abstract

INVESTIGATION OF ANTIBACTERIAL POTENTIAL OF ASCIDIAN, MICROCOSMUS EXASPERATUS (Heller, 1878) AGAINST HUMAN URINARY TRACT PATHOGENS

*G. Ananthan and K. Iyappan

ABSTRACT

The current investigation is based on the discovery of novel
antibacterial from new sources which have not been amply exploited.
The main objectives of this work was to ascertain the antibacterial
efficacy of a marine ascidian, Microcosmus exasperatus, collected
from Palk Bay, Southeast coast of India, against selected urinary tract
pathogens. The crude methanol extract was more active and exhibiting
a broad spectrum antibacterial activity than the crude ethyl acetate
extract against each of the bacterial strains tested. Maximum inhibition
zone (10.0 ± 0.1 mm) was observed against the gram negative
Pseudomonas aeruginosa in crude methanol extract. The consequent
zone of 6.5 ± 0.1 mm was observed in ethyl acetate extract in
P.aeruginosa.

Keywords: Microcosmus exasperatus, antimicrobial efficacy, zone of inhibition, urinary tract pathogens.


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