Abstract

IN-VITRO AND IN-SILICO SCREENING OF ACETYLCHOLINESTERASE INHIBITOR EXTRACTED FROM EPIPREMNUM AUREUM; A SOLUTION FOR ALZHEIMER’S

Shouvik Pine, Nitisha Bhargava and Guruprasad R*

ABSTRACT

Acetyl cholinesterase enzyme metabolise the transmission of action potential across the neuromuscular and catabolised the hydrolytic destruction of the cationic neurotransmitter acetylcholine. As acetyl cholinesterase (AChE) inhibitors play a fundamental role in therapeutic alleviate in Alzheimer’s disease .The naturally occurring organic compounds from plants are considered to be plenty source of new inhibitors has lead to the discovery of new drugs. In this paper we have isolated the inhibitors from Epipremnum aureum. This compound were documented by using GCMS, and simultaneously docking studies were done. We have analysis the efficacy of plant extract in both in-vitro and in-vivo condition by using zebrafish as a model organism. The plant extract has revealed many inhibitory activities in both in-vitro and in-vivo condition. With further research this compound may be used for the treatment of Alzheimer’s

Keywords: Acetylcholine, acetyl cholinesterase, GCMS.