Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF ‘PENTOXIFYLLINE, FLOATING TABLET

Pradip S. Patil* S.A. Tadavi, V.H. Jain and Dr. S.P. Pawar

ABSTRACT

Gastric emptying is a complex process and makes in-vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the gastric retention time of the drug-delivery systems for more than 12 hours. Floating drug delivery systems release gas (CO2), thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The recent developments of FDDS including the physiological and Formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail.

Keywords: FDDS, prolonged period, Bioavailability, gastric retention time etc.