Abstract

“SCREENING OF CARDIOPROTECTIVE AND ANTI-OXIDANT ACTIVITY OF TERMINALIA CORIACEA”

Sanjib Kumar Yadav* and Dr. Nagrathna P.K.M.

ABSTRACT

Objective: The aim of the current study was to evaluate the cardioprotective effect of the methanolic extract of Terminalia coriacea on doxorubicin induced cardiotoxicity. Methodology: For cardiotoxicity, thirty rats were evenly divided into 5 groups. Groups-1 served as controls, Group-2 standard drug treated group, Group-3 vitamin-E treated group, Group-4 test drug(low dose) treated group, Group-5 test drug(high dose) treated group and treatment is given for 7 days, On 8th and 9th day need to induce cardiotoxicity with doxorubicin, then on 10th day need to sacrifies rat then blood samples is taken for lipid profile test and the rat heart and liver for histopathology were obtained under inhaled diethyl ether anesthesia. Result: administration of doxorubicin in control rats showed a significant increase serum total cholesterol(TC), triglycerides(TG), lowdensity lipoprotein(LDL) and decrease in high density lipoprotein (HDL). Rats treated with hydromethanolic extract of Terminalia coriacea (200 mg/kg and 100 mg/kg) showed decreased TC,TG,LDL and increases HDL levels. The histopathological studies also showed that the plant extract significantly minimized the damage induced by doxorubicin. Conclusion: thus, Terminalia coriacea provide cardioprotection against doxorubicin induced MI in rates.

Keywords: cardiotoxicity, Terminalia coriacea, doxorubicin, MI, propranolol, vit-E and Albino rats.