Abstract

LIQUISOLID TECHNOLOGY: TECHNIQUE FOR FORMULATION WITH ENHANCED BIOAVAILABILITY

Patil Dhanashree Sanjay *, Magar Deepak, Saudagar Ravindra Bhanudas

ABSTRACT

Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble drugs. As these days there are many drugs in the market with poor solubility which leads to poor dissolution and bioavailability, so solubility is becoming rate limiting factor in the development of new drugs. The dissolution properties of a drug and its release from a dosage form have a basic impact on its bioavailability. Solving solubility problems is a major challenge for the pharmaceutical industry developments of new pharmaceutical products. There are various methods but liquisolidtechnique is a new and promising method that can change the dissolution rateof water insoluble drugs. With Liquisolid technique liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders by simple physical blending with selected excipients named the carrier and the coating material. The liquisolid approach has been successfully applied in release enhancement of low dose poorly soluble drugs.

Keywords: Liquisolid, bioavailability, dissolution, sustained release.