Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI-HYPERGLYCEMIC EVALUATION OF NEW METFORMIN DERIVATIVES

Yasir K. Mahdi*

ABSTRACT

Metformin is a cornerstone in the treatment of type 2 diabetes particularly in obese patients. Its main actions are the suppression of gluconeogenesis and the improvement of glucose uptake and insulin sensitivity. A series of metformin derivatives (III a-b) have been synthesized by reaction of metformin, chloroacetyl chloride and an appropriate phenol. The chemical structure of the intermediates and the final compounds were confirmed by measuring their melting points, FT-IR spectroscopy and HNMR spectroscopy of the final compounds. All the new compounds were evaluated for their anti-diabetic activity using streptozotocin induced diabetic rats model. Fasting blood glucose level was estimated on hours 0,2,5,6 and 24 from rat tail vein using glucometer. The newly synthesized compounds showed significant anti-hyperglycemic activity compared to metformin.

Keywords: metformin, anti-hyperglycemic activity, phenols, streptozotocin.