Abstract

NEW INSIGHTS INTO GASTRO-RETENTIVE FLOATING DRUG DELIVERY SYSTEMS

Manisha Ware*, Sandip Prasad Tiwari, Amit Roy, Trilochan Satapathy

ABSTRACT

In recent year, considerable attention has been focused on the formulation and development of new drug for orally targeted drug delivery systems. The oral route is most popular route of drug administration. Conventional dosage forms are unable to control either the rate or site of action. When a drug is delivered as a conventional dosage form they show very short gastric retention time. As such the drug which act locally in the stomach or get degraded by the colonic bacteria or/ and alkaline pH of the small intestine cannot be formulate as conventional dosage form. In conventional dosage forms, fluctuating drug level may lead to some side effect and dosing interval is short, this leads to poor patient compliance. At present a number of approaches are utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding system, mucoadhesive system, high density system, modified system and other delayed gastric emptying systems. Floating drug delivery systems has density lower than gastric fluid, so that it has tendency to float over gastric contents and remain in the stomach for prolonged period of time. The hydrodynamically balanced gastrointestinal drug delivery system is designed to prolong the GI residence in area of the GI tract to maximize the absorption of drug at the desired site in the solution form and hence increase the absorption.

Keywords: Gastric retention, FDDS, High density system, Mucoadhesive system.