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Abstract

METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF CLOTRIMAZOLE, FUSIDIC ACID AND MOMETASONE FUROATE IN CREAM BY RP-HPLC.

Devanshi G. Trivedi*, Ankit B. Chaudhary and Bhoomi D. Patel

ABSTRACT

The present work describes a validated reverse phase high performance liquid chromatographic method for estimation of Clotrimazole, Fusidic acid and Mometasone furoate in cream formulation. Chromatography was performed on a Hypersil ODS C18 column (250 × 4.6 mm, 5μm particle size) column with mobile phase containing 0.05M Potassium dihydrogen phosphate (pH 6.0 ± 1 % using Sodium Hydroxide): Acetonitrile (60:40). The flow rate was 0.8 ml/min and the eluent was monitored at 230 nm. The selected chromatographic conditions were found to effectively separate Clotrimazole (Rt- 4.277 min), Fusidic acid (Rt- 3.103 min) and Mometasone furoate (Rt- 5.707). Linearity for Clotrimazole, Fusidic acid and Mometasone furoate were found in the range of 10-30 μg/ml and 20-60 μg/ml and 1-3 μg/ml respectively. The proposed method was found to be fast, accurate, precise and reproducible and can be used for estimation of these drugs in cream.

Keywords: Clotrimazole, Fusidic acid, Clotrimazole, RP-HPLC, Estimation.


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