Abstract

DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLETS OF BAUHENIA VERIAGATA LINN

Amrita A. Kagalkar, Basavaraj K. Nanjwade* and Teerapol Srichana

ABSTRACT

Fast dissolving Tablets are disintegrating, dissolve immediately in the saliva without the need for water. FDTs can be prepared by different methods as direct compression, freeze-drying, spray drying, sublimation and wet granulation method. Botanical drugs comprise of a major share of all the officially recognised systems of health in India. The herbal extract of Bauhenia Veriagata Linn is used in this formulation. An objective of this study wwere to formulate FDTs with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water. To achieve this goal, MCC is used as diluents and sodium saccharin as sweetening agent for the formulation of tablets. Were attempt enhance dissolution rate along with faster disintegration using superdisintegrants like Crospovidone, Sodium starch glycolate (SSG) and mixture of crospovidone and sodium starch glycolatein the formulation of tablets. The tablets were subjected to weight variation, drug content uniformity and hardness, friability, wetting time, In vitro dispersion time, In vitro drug release studies and In vivo studies. In vivo studies showing the formulation F1 has antidiabetic activity.

Keywords: Fast dissolving tablets (FDTs); microcrystalline cellulose (MCC); crospovidone (CP); sodium starch glycolate (SSG).