Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF QUETIAPINE FUMARATE

Mangesh R. Bhalekar*, Ashwini R. Madgulkar, Anil V. Kadam, Abhilash D. Waghmare

ABSTRACT

The present study involves formulation and evaluation of a sustained release matrix tablet by using blend of hydrophilic polymers i.e. different viscosity grades of HPMC (HPMC K4M, HPMC K15M, HPMCK100M). The polymer blend was optimized using a simplex mixture design with constraints. The tablets were prepared by direct compression and formulations were evaluated for weight variation, thickness, hardness, friability and dissolution. The in vitro drug release was studied in simulated gastric fluid for 2h and in simulated intestinal fluid up to 20 h. The formula optimization was done for Release at 8 h and Release at 16 h. The polynomial equation generated was found statistically significant. Drug release from optimized batch was found to follow first order kinetics and extended to 20 h. Conclusion: Quetiapine matrix tablets of satisfactory hardness were produced. Furthermore, by blending Various Grades of HPMC in the matrix, tablets of varying release characteristics can be prepared.

Keywords: Quetiapine fumarate, Hydroxy propyl methyl cellulose, matrix tablet, sustained release.