Abstract

IN SITU GEL-NOVEL APPROACH FOR NASAL DELIVERY

J.U.Kute*, A. B. Darekar, R.B. Saudagar

ABSTRACT

Nasal delivery is a feasible alternative to oral or parenteral administration for some Drugsbecause of the high permeability of the nasal epithelium, rapid drug absorption acrossthis membrane and avoidance of hepatic first-pass metabolism. Besides this, intranasal routehas also been successfully exploited for bypassing the blood brain barrier and subsequentlydelivering drug molecules to central nervous system. In addition it minimizes the lag time associated with oral drug delivery and offers noninvasiveness, self-medication, patient comfort and patient compliance. Prolonged drug delivery can be achieved by various new dosage forms like in situ gel. In situ forming polymeric formulations are drug delivery systems. That is in sol form before administration in the body, but once administered, undergoes gelation, in situ to form a gel. In situ gelling systems are liquid at roomtemperature but undergo gelation when in contact with body fluids or change in pH in situ gelforming drug delivery is a type of mucoadhesive drug delivery system. Now a day in situ gel has been used as vehicle for the drug delivery of the drug for both local treatment and systemic effect. In situ gelling system becomes very popular nowadays because of their several advantages overconventional drug delivery systems like sustained and prolonged release of drug, reduced Frequency of administration, improved patient compliance and comfort.

Keywords: In Situ Gel, Gelation, Mucoadhesive.