Abstract

DEVELOPMENT AND INVESTIGATION OF MATRIX TABLETS OF TELMISARTAN FOR CONTROLLED RELEASE

Anupama S.*, Somashekar C. N. and Tamizhmani T.

ABSTRACT

The present study in the development of controlled release matrix tablets of anti-hypertensive drug Telmisartan. Hydroxy propyl methyl cellulose (HPMC) LV15 and LV5 used as a rate retarding polymer. The effect of the different proportion of the polymer and the influence of different grade of HPMC on the release rate of drug was investigated. Telmisartan release from HPMC LV15 and HPMC LV5 matrices are mainly controlled by the drug – HPMC ratio. When the influence of different grade of HPMC on the release of drug was examined, when the viscosity grade of HPMC increased there is decreased the drug release rate from matrix tablet. The tablets were prepared by direct compression methods and the prepared matrix tablets were evaluated for post-compression parameters such as hardness, friability, thickness, % weight variation, % drug content and in-vitro dissolution test.

Keywords: Telmisartan, controlled release, Hydroxy propyl methyl cellulose, Dissolution.