Abstract

TRANSDERMAL DRUG DELIVERY SYSTEM – A REVIEW

Nagappagari Madhuri*, E. Bhargav, Anand manne, V.Ravi, K.Ramesh

ABSTRACT

The human skin is a readily accessible surface for drug delivery. Over the past three decades, developing controlled drug delivery has become increasingly important in the pharmaceutical industry. Transdermal drug delivery system is a formulation that is applied to the body surface and is designed to deliver the active drug across the skin, into the systemic circulation. Today about 74% of drugs are taken orally and are found not to be as effective as desired. To improve such characters trans dermal drug delivery system was emerged. Trans dermal delivery offers several advantages over conventional routes including avoidance of pre systemic and systemic first pass metabolism, improved patient compliance, reduced side effects and controlled release over extended period besides providing a convenient non-invasive delivery. This article deals with a brief insight on the introduction, the formulation aspects, permeation enhancers and evaluation aspects of transdermal drug delivery system explored to enhance the trans dermal delivery of drugs across the stratum corneum.

Keywords: Transdermal drug delivery, Permeation enhancers, Stratum corneum.