TARGETED DRUG DELIVERY- A REVIEW
E.Bhargav*, N.Madhuri, K.Ramesh, Anand manne, V.Ravi
ABSTRACT
At present 95 percent of all new potential therapeutics have poor
pharmacokinetic and biopharmaceutical properties. Hence there is need
to develop a suitable drug system that distributes the therapeutically
active drug molecule only to site of action, without affecting healthy
tissue or organ. Among drug carrier soluble polymers, microparticles
made of insoluble (or) biodegradable natural and synthetic polymers,
microcapsules, cells, cell ghosts, neutrophils, fibroblasts, artificial
cells, lipoproteins, lipososmes and micelles, immune micelle,
monoclonal antibodies can be taken into consideration. Liposomes are
micro particulate lipoidal vesicles which are under extent of
therapeutic investigation as drug carriers for improving the delivery of
therapeutic agents. Most clinical applications of liposomal drug delivery are targeting to
tissue with or without expression of target recognition molecules on lipid membrane.
Microspheric drug delivery system has gained enormous attention due to its wide range of
application as it covers targeting the drug to particular site to imaging and helping the
diagnostic features. In future by combining various other strategies, microspheres will find
the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene
& genetic materials. Monoclonal antibody technique involves fusing a normal antibody
producing B cell with a myeloma cell to produce a hybrid cell or hybridoma they are
excellent candidates as carriers of therapeutic agents for delivery to specific sites. This paper
explores various aspects of nanoparticles, microsphere, liposomes and monoclonal antibodies
formulation, characterization, effect of their characteristics and their applications in delivery
of drug molecules.
Keywords: Targeted drug delivery, Microspheres, Nanoparticles, Liposomes, Monoclonal antibodies.
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