Abstract

A COMPARATIVE STUDY OF THE EFFECT OF VARIOUS KINETIC PARAMETERS ONSYMMETRIC REDUCTION OF KETONES USING TETRABUTYLAMMONIUM FLUORIDE AND POLYMETHYLHYDROSILOXANE

Mohammed Said Nedjimi, Kedadra Abdellatif and Lakhdar Sekhri*

ABSTRACT

The present work is aimed mainly to investigate and find optimal conditions by changing various kinetic parameters on reaction conversion such as duration of reaction, effect of temperature, and solvent. THFwas found to be the best solvent for this mild reduction of carbonyl compounds. These optimal conditions were applied on fundamental and practical PMHS/TBAF reduction reaction of carbonyl compounds. This study underscored the reduction of various acetophenone derivatives, 4'-haloacetophenones (X=F, Cl and Br) and 4'-nitroacetophenone andthe chemical yield could reach about 80%. The results obtained in the present studysuggest that the thePMHS/TBAFcan be used as catalyst in synthesis many pure pharmaceuticals. Thesereveald that the PMHS/TBAFis an excellent reducing agent for the mild reduction of ketones and aldehydes.

Keywords: TBAF, PMHS, reduction, alcohols, acetophenones, pharmaceuticals.