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Abstract

DEVELOPMENT OF LEVOFLOXACIN LOADED NANO-NIOSOMES AS NANOSCALE DRUG DELIVERY FOR EFFECTIVE TREATMENT OF TUBERCULOSIS

Ranjini D. S., Parthiban S.*, Senthil Kumar G. P. and Tamizh Mani T.

ABSTRACT

The main objective of the present study was to encapsulate Levofloxacin in nano-niosomes for achieving prolonged release & longer duration of action. Nano-niosomal formulations were prepared by using different ratio of surfactant (Span 60) and cholesterol by thin film hydration followed by sonication method and was evaluated for entrapment efficiency, particle size, zeta potential, surface morphology and in-vitro drug release. Particle size and zeta potential of the F3 formulation was found to be 303.5 nm and -42.6mV respectively. Highest entrapment efficiency was observed in F3 94%. The percent drug release from F1-F3 was observed as follows F1- 86.89%, F2- 74.62%, F3- 59.44% which follows zero order drug release and Non- Fickian diffusion mechanism.

Keywords: Levofloxacin, Tuberculosis, nano-niosomes, thin film hydration method, stability studies, In-vitro release.


[Full Text Article]

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