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Abstract

STUDY OF THE EFFECT OF THE EXTRACT OF THE LEAVES OF ALTERNANTHERA BRASILIANA IN EXPERIMENTALLY INDUCED INFLAMMATORY BOWEL DISEASE IN EXPERIMENTAL ANIMALS

Dr. Chimi Handique*, Dr. Mangala Lahkar and Dr. Arijit Dutta

ABSTRACT

Objectives: To evaluate the effect of the ethanolic extract of leaves of Alternanthera brasiliana (EEAB) in different doses in 2,4,6- Trinitrobenzenesulfonic acid (TNBS) induced inflammatory bowel disease in albino rats. Methods: The study was done on healthy albino rats in the Department of Pharmacology of Gauhati Medical College. They were housed in standard laboratory conditions. There were 6 groups each consisting of 6 animals. The groups were Group I (Normal Control), Group II (Disease Control), Group III (Standard), Group IV (EEAB 200 mg/kg), Group V (EEAB 400 mg/kg) and Group VI (EEAB 600 mg/kg). Experimental colitis was induced in all the groups except in Group I on 1st day. The animals were treated with sulfasalzine and different doses of the extract for the next 14 days. The animals were sacrificed on 15th day under anaesthesia. The colonic damage was assessed by observing the colon weight change, macroscopic and histopathological examination. Results: The data was analyzed using ANOVA and Dunnett’s test was used as post ANOVA analysis using Group II as control column. The results with p<0.05 are considered to be significant. Conclusions: The EEAB was found to have significant anti-inflammatory activity in experimentally induced colitis as shown by the decrease in the colon weight, macroscopic score and histopathological score.

Keywords: Alternanthera brasiliana, Experimentally induced colitis, TNBS induced colitis, Anti-inflammatory activity.


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