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  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

DEVELOPMENT & VALIDATION OF A UV VISIBLE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF LOVASTATIN IN BULK AND PHARMACEUTICAL DOSAGE FORM.

Narad Vaibhav R.*, Dr. Dhobale S.M. and Dr. Gaikwad D.D.

ABSTRACT

The aim of present investigation involved development of an accurate, simple and cost effective UV-spectrophotometric method for estimation of Lovastatin in bulk and in pharmaceutical dosage form. The UV-spectrum showed that maximum absorbance of light was observed at 248 nm and followed linearity in the range of 5-25μg /ml having value of correlation coefficient, 0.9988. This proposed investigation was validated as per ICH guideline Q2 (R1) for linearity, accuracy, precision and recovery. The satisfactory value of percent relative standard deviation for the intraday and inter-day precision indicates that method was precise. Result of the recovery studies (98.73) showed accuracy of method. The investigated method can be used for estimation of lovastatin in bulk and dosage form.

Keywords: The aim of present lovastatin in bulk and dosage form.


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