Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

TREATMENT OF HYPERPIGMENTATION USING Terminalia Catappa WITH ZEBRAFISH AS A MODEL

Sankara Kumar K.*, Ramesh Kani K., Saravanan N., Ramesh Babu N. G. Guruprasad R.

ABSTRACT

Terminalia catappa is a plant known for its medicinal values. It is rich in tannins and flavonoids. It is checked for the presence of the enzyme, Tyrosine Ammonia Lyase (TAL). It converts tyrosine into p-coumaric acid and eliminates non-oxidative ammonia. The crude enzyme was extracted and assay was done using tyrosine as a substrate and tested for the presence of p-coumaric acid. The absorbance value at 410 nm showed the presence of p-coumaric acid and the presence of TAL in the crude enzyme. The methanol extract of Azadirachta indica (neem) is shown to enhance the activity of TAL enzyme. The dry leaves of Azadirachta indica were extracted by methanol using Soxhlet extractor. The extract was added to the crude enzyme and the increase in activity was observed by assay. The activator-enzyme mixture was then used to study its anti-hyperpigmentation activity by using zebrafish as a model. Dechorionated embryos of zebrafish were used as in-vivo models and incubated with the activator-enzyme mixture. The decrease in pigmentation proved that it can be used as a viable drug against hyperpigmentation.

Keywords: Tyrosine Ammonia Lyase, Hyperpigmentation, Zebrafish, Dechorionation.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More