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  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULTION AND IN VITRO EVELUATION OF FLOATING MULTIPARTICULATE DRUG DELIVERY SYSTEM OF AMOXICILLIN

Faheem Unnisa Begum*, Pamu Sandhya and Zaara Majeed

ABSTRACT

Gastro retentive drug delivery system have been developed for prolonged gastric residence time (GRT), extended release devices with reduced frequency of administrstion and also improved patient compliance. The purpose of designing gastro retentive floating multi particulate beads of Amoxicillin dosage form is to develop a reliable formulation that has all the advantages of a single unit formulation and yet devoid of the danger of alteration in drug release profile and formulation behavior. The reason for selection of Amoxicillin as a candidate for the study was Amoxicillin has the absorption window in upper part of GIT. Amoxicillin along with excipients sodium alginate, hydroxyl propyl methyl cellulose, calcium chloride, calcium carbonate was prepared as gastro retentive floating beads. The beads were evaluated for drug encapsulation efficiency, buoyancy test, FTIR study, scanning electron microscopy analysis, in vitro dissolution studies and drug release kinetics. Optimised formula of F4 showed better release profile and extended the drug relese for longer duration of time upto 12 hours. The drug release pattern from the optimized formulation followed zero order kinetics. The floatation was accomplished by incorporating gas generating agent calcium carbonate into a swellable polymer. FTIR studies of the pure drug and formulation showed that there was no drug polymer interaction. The physio chemical properties of all the formulations were found to be within the prescribed official limits. The optimized formulation have 99.87% of drug release upto 12 hours in a controlled manner.

Keywords: Gstro retentive, Floating multi particulate, Amoxicillin, Controlled release, FTIR.


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